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And it wasn't particularly easy. I waited until 3 months past my COVID infection and then discovered that there was a month's lead time on scheduling vaccines at Health Partners. Cub Pharmacy seemed to have loads of appointments, but the scheduling engine was completely broken (which I suppose is why all those appointment slots were open). I found out later that they did accept walk-ins, but you couldn't tell that from the website. 

The Walgreen's scheduling engine worked fine, but there were no appointments anywhere in less than a week and no convenient ones in less than 2 weeks. I went with convenience over urgency, and my appointment finally came up yesterday. Went relatively smoothly, except for having to fill in the check-in form again on paper because they couldn't retrieve it from the computer system. The shot itself is so tiny - I literally didn't even feel it. My arm is a little sore today, but no other side effects. I got my flu shot last week (walk-in at Cub) so I don't have the double sore arm problem. I'm glad I didn't get both shots at once, since last week's hi-dose flu shot gave me a sore arm for a week, much worse than usual. 

The guy who gave me my shot said that demand has been sky-rocketing in the past week or two as people look towards the holidays. There has been a lot of official hand-wringing over the low uptake of the new booster, but I can't help but think this is partly illusory. Perhaps the health care establishment hasn't noticed that they are providing 3 contradictory sets of advice on boosters (as well as giving the impression that boosters are trivially easy to schedule, which I did not find to be the case).
  1. Get your booster NOW NOW NOW! Do not delay! This is very important!
  2. Unless you've had COVID in the past 3 months (as maybe 20% of the population has) in which case you might as well hold off
  3. Or unless you have travel plans in the next few months, in which case you should wait
I'm probably not the only person trying to follow recommendations 2 and 3, while underestimating the scheduling issues. 

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Richard wanted to get his bivalent booster as soon as possible and we found it impossible to get it from his usual Walgreens. They had the vaccine but wouldn't give it to him unless he made an appointment in advance over the phone or online (forget walk-ins, they wouldn't even schedule an appointment in person). The pharmacy doesn't answer their phone and this location did not show up in the online scheduler. So I tried CVS online. Again, nothing at any nearby location, but the CVS pharmacy inside the Target on 66th and Cedar had availability the next day. I managed to schedule the appointment, although it was a PITA (they demanded every possible number from his insurance card PLUS his Medicare number, which their website repeatedly refused to accept). I finally just ignored the bogus error messages and continued on and the appointment was made. I reluctantly gave them my cell phone number because otherwise the whole process would have had to be aborted. 

Richard then spent 90 minutes in the Target store the next day, which apparently had no signs directing people on where to go for vaccinations. He waited in line at the mini-clinic for a long time only to find that he had to go to the pharmacy instead. Then again had to wait in a long line of people filling prescriptions, so was late for his scheduled appointment. But they did vaccinate him. 

I knew I should never have given CVS my phone number. One reason I switched to the Cub Pharmacy for my own prescriptions was to get away from their inane "courtesy calls." Sure enough, they called for Richard this morning, refusing to leave a message or give a reason for the call. On the off chance that they were calling to say they had given him the wrong vaccine or something, we fought through the phone tree and hold queue to get back to them. Yup, it was a marketing call. They wondered if Richard might like another random vaccine that he does not in fact need (pneumonia). 
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It's exactly 2 weeks since I tested positive for COVID and I feel fine!  I thought I felt fine 3 or 4 days ago, but I feel better now. I'm actually feeling energetic, which is much better than "I no longer have trouble staying awake in late afternoon." My post-COVID sniffles and cough have seamlessly transitioned to My Normal for mid-August (hello, ragweed pollen!). I thought I was well when my appetite came back, but it came back kind of unhinged, with my body trying to gain back the 3 pounds I lost while sick. Today I'm just normally hungry and able to consider eating balanced meals instead of unlimited amounts of ice cream. So I went grocery shopping and stocked up on healthy food.

The rest of today is slated for Putting Stuff Away

I found some good deals on fresh meat (as I always seem to at Cub), but some of it is in large packages that must be broken up and labeled and frozen. I stocked up on toilet paper, which must be stashed behind the towels in the linen closet. I've removed the car seats from our vehicles, packed them back into their enormous boxes, and wrestled them down to the basement. Over the course of the past 3 days I have packed up all those bulky toddler toys I got for the grandkids' visit and now must find somewhere to put THOSE boxes. And then there's a ridiculous project involving moving many boxes of comic books so I can access a hidden outlet behind a heavy oak shelving unit. And then putting the comics back, which matches the theme for the day. 

 
 
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Lena and I finally tested negative today, on Days 10 and 9 respectively. Olin and Amber are faintly positive, Amber's line nearly invisible but detectable. We haven't tested the boys, who seem fine except for occasional coughing. Richard still has no symptoms and has only tested negative to date. So we are mostly still isolating at home, with occasional forays to local parks. 

Among other things, I have pulled out all my old kitchen gadgets and we are trying them out. The little ice cream/ yogurt maker is a big hit with the boys.




Leo goofing around at the front door, looking like a monster baby.

The boys playing with the blue wagon in the back yard.

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It's now Day 8 for Lena (Days 4-7 for the rest of us), with Richard still evading infection. We're all feeling pretty good, with a few lingering symptoms, but we still can't go anywhere. Incidentally, Lena still tests strongly positive despite being over all her symptoms. I finished a full course of Paxlovid yesterday and now feel well, but still tested weakly positive this  morning. Amber is at Day 6 and also weakly positive. So I continue to be deeply skeptical of the CDC's horrible outdated isolation advice, which strongly implies that contagion "normally" ends at Day 5. This is absolutely not true. There is now data (which you can find on the CDC site itself if you search hard!) that specifically shows that 50% of COVID patients are still contagious at Day 5. 25% are still contagious at Day 8. It isn't until Day 10 that most people are finally non-infectious. Amber managed to change their flight home to Thursday, by which date everyone in her family should be past Day 10. It is terrifying how many people are flying these days after a completely inadequate 5-day isolation period. 

Amber and I resurrected an ancient iPad version 1 (from 2011?) and managed to find a few toddler apps on the app store that still work. This has kept Harris and Leo happy except for when they are fighting over which one gets to execute Humpty Dumpty or chop the tails off the Three Blind Mice (a particularly grotesque nursery rhyme game is a favorite). 

Meanwhile, Olin and Lena went out for a drive (in the rain, because they were getting desperate for something to do) and ventured out of the car at a deserted sculpture park long enough to get a beautiful iteration of the standard Minneapolis Tourist Photo. 





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Thorin tested positive today, despite having isolated himself almost completely in his room. We are amazed that it got him but (so far) not Richard. But at least now he is willing to join in some family time, which he wouldn't do before, even outside.











It seems unfair that Thorin got infected after taking such extreme precautions, but at least he can play with the kids now. He's a good uncle. Right now he's helping Lena learn a complicated computer game called Outer Wilds. She's turned into quite a good little gamer.  

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Harris, the toddler that was really sick yesterday, is better today. He's still a little droopy but his fever is down to 100.4, he is asking for food and liquids, and even cooperating when his parents want to take his temperature. Leo clearly has it too, but it doesn't seem to be bothering him much. His temperature this morning was 101 (still in the "low-grade" category) and he has a little cough. 

And I tested positive this morning. I felt it coming on last night, and this morning I felt like I was definitely getting a cold. Slightly running nose, more of a cough than I usually have, slight sore throat, and a weird faintly dizzy feeling sometimes when I turn my head. The pink line on the antigen test lit up almost instantly, brighter than the comparison line. 

I immediately set my plan in motion to get Paxlovid. First step is to schedule a PCR test at Health Partners. Okay, easy enough to do that online. Except... something was wrong with the website this morning and it kept timing out with random error messages. It took me about 15 minutes of constant retrying to force my way through, but I got an appointment for 12:30 in St Louis Park. Presumably, the results will be forwarded to HP's COVID Response Team which will immediately get back to me with treatment options. I figure there is maybe a 50% chance of that actually happening? 

Have any of you successfully gotten a Paxlovid prescription, or known anyone that has? I know 3 people who did and they all say that they felt better within hours of starting it. So I hope this works. 

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Lena wasn't terribly sick all day yesterday, but by bedtime she felt hot to the touch and was starting to feel slightly nauseated and chilled. A search of the medicine cabinets turned up none of those new-fangled electronic thermometers and no children's Tylenol, nailing us as totally unprepared grandparents. We did find an old mercury thermometer, which read 102. Yikes, that's an actual full-fledged fever! So Olin was sent out to an all-night pharmacy for Tylenol, which seemed to help. I worried about Lena all night, but she slept soundly after the Tylenol and woke up cheerful and energetic. She still has a little cough and feels a little warm, but not enough to even bother with Tylenol. I think she is on the mend. 


Amber tested positive this morning, and Harris is clearly sick. Amber is still pretty perky, but Harris clearly feels miserable. Olin and Leo feel fine. Leo had a great time all morning, playing with trains and doing a Sisyphus routine with an exercise ball he liberated from the attic. 


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Good news: the grandkids are here!!
Bad news: Lena has COVID.

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 Scott Raun posted this in a thread on natter (thanks, Scott). Posting it here so I have the link handy if I need it later. Also, I guess, to boost the signal, although I doubt there are very many people who read my Dreamwidth who don't also read natter. I checked out the website and it's amazing! It looks like every pharmacy, clinic, and hospital is listed. There are 135 within 10 miles of my zipcode, including many institutions I have never even heard of. The treatments available at each location are listed: both Paxlovid and molnupiravir are available, although not necessarily at the same locations. 

This is a HUGE leap forward from the convoluted and unworkable procedure that was in place 2 months ago when I asked my doctor about it. 

This is what I have been waiting for to put my mind at ease about COVID. As someone over the age of 70 with a few comorbidities, I should qualify for Paxlovid. Between that and vaccinations and the less virulent Omicron variants, I'm pretty sure I'm not going to die of this thing. 

The Federal Government has a Test-to-Treat program.  You can find
information and participating locations at:

https://aspr.hhs.gov/TestToTreat/Pages/default.aspx

There's at least one, possibly two, anti-virals specific to COVID
available.  The sooner you start taking them, the better.
Test-to-Treat is basically 'walk in, get tested, get treatment if
you're positive'.

 
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It's now 5 days past my most likely Minicon COVID exposure (the final party at our house) and I'm not feeling great. No specific symptoms except exactly what you would expect when the spring tree pollen count is peaking (which it is). But I am still so tired no matter how much I sleep. And there's a game party at our house tonight, so why not be careful? 

Test was negative. I'm fine, just tired out. 

I haven't heard of any Minicon-related COVID infections. Has anybody else?  Anybody else testing? 
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As I have commented before, a policy of endless boosters of the original vaccines at constantly decreasing intervals is not a viable long term strategy for combatting the evolving coronavirus. It might be worth pursuing as a short-term crisis response targeted to vulnerable people, but more data is desperately needed. And of course what we really need is those next-gen vaccines that are reportedly under development now. Here's some good news on both fronts.

I just found this article about a study that NIAID is sponsoring at the University of Rochester that will both evaluate the efficacy of booster #2 and (more excitingly) fold in trials of "new investigational vaccines that target the Beta, Delta, and Omicron variants." 
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Fact: There is some evidence for the efficacy of a 2nd COVID booster, but the data is sparse. Mostly two preprint studies from Israel, one of which suggests that 4th shots in the midst of a massive Omicron spike significantly reduces mortality/hospitalizations in the elderly. The other one showed minimal efficacy for middle-aged health care workers (average age 50), arguably because they were young and healthy enough to have reached peak vaccination-fueled immunity already and had little to gain from another boost. But in neither case was there any sign of harm. There is, as far as I know, no data to show that another booster does anything to reduce transmission of the current viral variants - we're just talking about preventing catastrophic outcomes for the people that are infected. So whether or not to get that 2nd booster right now is a matter of personal risk management, not public health. 

One interpretation of all this is "Get the booster if you are eligible. It might help and it almost certainly won't hurt. And it's free, so why not?" Okay, that makes sense. Richard is going with that philosophy, and just got his 2nd booster today. 

My viewpoint is slightly different. It seems pretty clear that the effect of an mRNA booster shot is a large but transitory surge in coronavirus antibodies. Originally everybody hoped that the first booster shot would result in greatly improved long term immunity. That was revised downward to 8 months, then 6 months, and now the advice is to get another booster after 4 months. Immunity doesn't drop suddenly like falling off a cliff - it drifts downhill. If the current thinking is that the booster has pretty much worn out by 4 months, that suggests that it gives you at most 2 or 3 months of robust additional immunity. 

It seems to me that the time to get a booster that will only protect you for 2 or 3 months is at the BEGINNING of a COVID surge, not at the end. So my plan is to wait until the roller coaster starts up the next hill for that booster, not to waste my two months of turbo-charged immunity in a flat period. 

Of course, the next surge may well be in the offing. Minnesota releases its weekly infection numbers on Monday. Last Monday, the decline had essentially plateaued. Today the new numbers came out, and it's up 9%. Still under 10 cases/100K, but moving the wrong direction. The wastewater surveys the last couple of weeks have also reported increases. So I'm biding my time, but watchful. 

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Daily case count (averaged over 7 days) has plummeted another 45% to 2,324. We're now down to slightly below where we were at Christmas, just before the sudden Omicron surge started. Our graph looks much like everybody else's Omicron graph (4 weeks up, 4 weeks down) except that we were still on the Delta downslope when our Omicron peak started upwards. 

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This is confusing because I always have a runny nose, and it's been particularly bad this winter. But it's been worse the last 2 or 3 days, with lots of sneezing. Am I sick? I did go grocery shopping on Monday (in an N-95 mask, but still...). Other than that, haven't seen anybody outside my household for a week and that was just one fully vaccinated person. So technically I COULD have COVID but it doesn't seem very likely.

Usually the way I tell the difference between allergies and a cold is that with a cold my first symptom is invariably a sore throat. No sore throat. In fact, I feel just fine except that my nose won't stop running. It seems to get better when I leave the first floor, so maybe there's something down there that I'm allergic to. 2 months ago it was the Christmas tree, but that's been gone for 6 weeks now. I made Richard vacuum under the radiators and behind the furniture just in case there was still Christmas tree dust under there. Then my nose felt worse. But I guess that's what would happen if somebody moved all the furniture and stirred up the allergenic dust, right? Now I'm up in the computer room and breathing easier. 

If I don't feel better tomorrow I guess I'll use up one of our precious home COVID tests. I'm not sure what to do if it's positive, though. Call a doctor, I guess, and see if I'm eligible for one of those courses of Paxlovid that are apparently just sitting and gathering dust on pharmacy shelves right now because doctors aren't sure when to prescribe them and nobody knows which pharmacies have them. 

ETA: just to see how hard it was to schedule a PCR test with Health Partners I logged in and started the process. One of the first questions is a list of symptoms that you might or might not have. Runny nose / congestion is not even listed, despite the fact that it is the NUMBER ONE SYMPTOM of an early Omicron infection. However, the fact that I do not have a single one of their out-of-date list of symptoms did not stop them from offering me a test slot at a drive-in Bloomington clinic tomorrow morning. Which I did not take - I just wanted to see what was possible. Actually as I type this my nose feels much better. I may have to just stay out of the living room. Could there be a cat hiding down there somewhere? 
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As is probably obvious from my posts, I have always been fascinated by health topics. If you don't share this interest, the rest of this post will probably be tldr.

With all its horrors, this pandemic has given us (the big societal "us") a treasure trove of new knowledge about how the immune system works. Some of this is apparently new to scientists and public health experts; some is just new to me. This particular nugget is probably the latter, but it's something that never occurred to me before and it took a while to penetrate. I realize now that I have seen this explanation before, but I just didn't get it.

Apparently it makes a difference to the immune system exactly where in the body a vaccine is administered. There is not only a systemic reaction to the vaccine, there is also an effect that is purely local. That is why you get a sore arm in response to a vaccine shot - the tissues around the shot are having a small local overreaction to the vaccine stimulus. That doesn't really hurt anything but is not helpful. The goal is the larger systemic reaction. But if there's going to be a local reaction, it would be more helpful if that occurred at the same location where the virus enters the body.

So THAT'S the real reason that they're working on a coronavirus vaccine that can be delivered via nasal spray! It's not just because it's less unpleasant, it's because stimulating the mucosal membranes may actually produce a long-lasting immune response IN THE NOSE. Wow. Another reason to look forward to the next generation of coronavirus vaccine, currently under development. Maybe that one will even provide some protection for the common cold. Wow.

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About 3 weeks ago the Poop Patrol in Minnesota reported that the traces of coronavirus in Minnesota wastewater were dropping precipitately, but you couldn't see the peak on the COVID arrival graph until Jan 25 (peaking out at 16,578 new cases). This is reportedly because the staff who enter the data for Minnesota Dept of Health were either overwhelmed or out sick, and it took them a while to catch up. Jan 25 looks like they pulled an all-nighter and got the data stream back on track. Good work, guys! 

Anyway, it's been falling like a stone ever since. I'm still finding articles online from as recently as a week ago listing Minnesota as one of the states where the rate is still increasing, but a week ago is like a year ago these days. We're plummeting downwards, even with some outstate areas trailing the metro and holding the average back a little. Now the question is... will it go back to where it was before the Delta wave hit in late summer, or will Delta somehow resurface and continue its course? I like to believe that Omicron wiped out what was left of Delta, which might take us back to ground zero (which is not actually zero, of course, but 89 sure looks like zero compared to 16,000). 

~~~~~~~~~~~~~~~~
Has anybody gotten those free COVID tests that we all ordered from the government on Jan 18? We haven't. Haven't needed them, though, because we haven't gone anywhere except grocery shopping since Christmas. I haven't had so much as a cold since November 2019, when I last passed unmasked through an airport. 

~~~~~~~~~~~~~~~~~
So how do you decide when it's safe to take a few more risks? For me, that would be visiting an indoor restaurant or gym, both things I would like very much to do. For Richard that would be hosting a game party. Since we are planning a trip to Oregon in mid-March, I guess we'll keep a low profile until then. We have a vacation house rented in Depoe Bay for a couple of days of whale-watching, and I don't want to have to cancel that. Barring another big COVID surprise, we'll probably start opening up after that. 


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I have been watching "Twelve Monkeys," an SF series based on the apocalyptic pandemic movie of the same name. It's a solidly well produced show which does its best to be scientifically plausible (insofar as a show about time travel can be). But it was made 6 or 7 years ago, and what seemed plausible then sounds really dated now. 

We've just been introduced to a cohort of scientists, barricaded inside a well-supplied and prosperous scientific hospital, who have been trying to "cure the virus" for almost 30 years. Specifically, they have devoted every resource at their disposal to trying to create a vaccine. After 20 years they were right on the verge of a working vaccine, but THEN THE VIRUS MUTATED!  *gasp* So they had to start all over!  Worse yet, there are signs that the virus is starting to mutate again! Oh no!  Naturally the more ragtag group of scientists that we have been rooting for so far realizes that this is a fools' errand, because nobody can create a working vaccine that fast. We the viewers are invited to agree with them and view the lead scientist of the Spearpoint Project as most likely inspired more by his status as a cult leader than by any reasonable expectation of developing a vaccine against a virus that can mutate as often as twice in 30 years!  Ridiculous. Our group is going to keep trying to perfect their buggy time travel machine instead. 

IRL in 2022 we are upset because when faced with a virus that has developed multiple significant mutations in 2 years time, the vaccine that we developed (in 12 months) is becoming gradually less effective. And it might take as long as THREE MORE MONTHS to develop a new vaccine that will better target the emerging variants. Unacceptable! 
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 ... is right twice a day. And today that stopped clock is the odious Florida Governor DeSantis, who has been saying that the hospitals need to start distinguishing between those hospitalized with COVID and those who "just happen to have it."  He is right. COVID hospitalization numbers have been contaminated by this problem since the start of the pandemic. Which might be okay if the percentage of incidental COVID infections among hospitalized patients had been staying steady. The number might be inaccurate but it should remain a good basis of comparison between one wave and the next.

But that is not what is happening. With the Omicron wave there are now so many people with asymptomatic or trivial COVID infections that in hot spots like New York City most of the COVID hospitalizations were not actually hospitalized for COVID. That makes the "number of COVID hospitalizations" a pretty meaningless number. Although it might provide some insight into what percent of the population is already infected with Omicron.

Dr. Fritz François, chief of hospital operations at NYU Langone Health in New York City, said about 65% of patients admitted to that system with COVID-19 recently were primarily hospitalized for something else and were incidentally found to have the virus.
...
At two large Seattle hospitals over the past two weeks, three-quarters of the 64 patients testing positive for the coronavirus were admitted with a primary diagnosis other than COVID-19.

This is actually good news, in a way. It means that Omicron hospitalizations are even lower than the already much diminished numbers being reported.